GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs4459386 | 1 | rs10783342 | chr12:50628466 | SMARCD1 | chr12:50478983-50494493:+ | -0.14 | -3.92 | 9.27E-5 | Schizophrenia |
| BRCA | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | B4GALNT1 | chr12:58019551-58026985:- | 0.12 | 3.6 | 0.000339 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 10.78 | 8.53E-26 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | TSFM | chr12:58176536-58191367:+ | -0.34 | -10.39 | 3.71E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10783847 | chr12:58196447 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.18 | -5.22 | 2.21E-7 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | B4GALNT1 | chr12:58019551-58026985:- | 0.12 | 3.63 | 0.000293 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | FAM119B | chr12:58166383-58176323:+ | 0.43 | 11.04 | 6.59E-27 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | TSFM | chr12:58176536-58191367:+ | -0.34 | -10.35 | 5.57E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10783848 | chr12:58196528 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.17 | -4.96 | 8.29E-7 | Multiple sclerosis |
| BRCA | cis | rs11174436 | 1 | rs10784292 | chr12:62740429 | FAM19A2 | chr12:62102043-62653925:- | 0.18 | 3.95 | 8.25E-5 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs10784295 | chr12:62822893 | FAM19A2 | chr12:62102043-62653925:- | 0.16 | 3.44 | 0.000614 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs10877945 | 1 | rs10784325 | chr12:63440052 | PPM1H | chr12:63037763-63328915:- | -0.14 | -3.61 | 0.000324 | Obesity-related traits |
| BRCA | cis | rs10784762 | 1 | rs10784762 | chr12:69523923 | YEATS4 | chr12:69753532-69784575:+ | -0.12 | -3.61 | 0.000316 | QRS duration |
| BRCA | cis | rs4118325 | 1 | rs10785814 | chr1:107610540 | NTNG1 | chr1:107682629-108024471:+ | 0.16 | 3.54 | 0.000421 | AIDS |
| BRCA | cis | rs4118325 | 1 | rs10785814 | chr1:107610540 | PRMT6 | chr1:107599267-107601907:+ | 0.22 | 4.46 | 9.1E-6 | AIDS |